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Medical terminology API: LOINC, SNOMED, ICD-10, RxNorm

Where to look up each medical code system for free, how codes appear in FHIR, and what Anpheros includes (a small LOINC/ATC subset and symptom concepts) — honestly scoped.

A medical terminology API lets software search and look up standard medical codes — LOINC for tests and measurements, SNOMED CT for clinical terms, ICD-10 for diagnoses, RxNorm and ATC for medicines — so data from different sources means the same thing. Each code system has its own owner, licence and lookup service, and most are free. This page lists where to look up each one, how they appear in FHIR, and what Anpheros includes so your app can store coded data without running a terminology server.

Where to look up each code system
LOINC — lab tests and measurementsloinc.org search; FHIR terminology server fhir.loinc.org (free LOINC account)
ICD-10-CM — diagnoses (US)NLM Clinical Tables API, free and keyless
ICD-10 / ICD-11 — diagnoses (WHO)WHO ICD API, free registration
SNOMED CT — clinical termsSNOMED browser and Snowstorm; licence via your country
RxNorm — US medicinesNLM RxNav REST API, free
ATC — medicine classesWHO Collaborating Centre index; bundled subset in Anpheros

Free lookup services

Code system Used for Lookup service Access
LOINC laboratory tests, vital signs, documents loinc.org, FHIR terminology server fhir.loinc.org free, LOINC account for the FHIR server
ICD-10-CM diagnoses (US) NLM Clinical Tables API free, no key
ICD-10 / ICD-11 diagnoses (WHO, most countries) WHO ICD API free, registration
SNOMED CT clinical findings, procedures, body sites SNOMED International browser; Snowstorm (open-source server) free in member countries; licence needed elsewhere
RxNorm US medicines NLM RxNav REST API free, no key
ATC medicine classes (WHO) WHO Collaborating Centre index free to look up

A quick ICD-10-CM search, with no key:

curl "https://clinicaltables.nlm.nih.gov/api/icd10cm/v3/search?terms=asthma&maxList=5"

How codes appear in FHIR

Every coded element in FHIR is a CodeableConcept: one or more codings, each with a system URI and a code, plus the original text.

Code system FHIR system URI
LOINC http://loinc.org
SNOMED CT http://snomed.info/sct
ICD-10 http://hl7.org/fhir/sid/icd-10
ICD-10-CM http://hl7.org/fhir/sid/icd-10-cm
RxNorm http://www.nlm.nih.gov/research/umls/rxnorm
ATC http://www.whocc.no/atc
UCUM units http://unitsofmeasure.org

What Anpheros includes

Frequently asked questions

Is there a free LOINC API?

Yes. LOINC provides a FHIR terminology server at fhir.loinc.org for registered users (registration is free), and the NLM Clinical Tables API offers a keyless LOINC search.

Is there a free ICD-10 API?

Yes. The NLM Clinical Tables API searches ICD-10-CM without a key, and the WHO ICD API covers ICD-10 and ICD-11 after free registration.

Do I need a licence for SNOMED CT?

In SNOMED International member countries (including the US and most of the EU) use is free under the national licence; elsewhere a licence is required. Check your country's National Release Centre.

Does Anpheros include a full terminology server?

No. It includes a small LOINC and ATC subset and a symptom knowledge base, and stores any valid code. For full lookups, use the official services above.

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